Transdermal Product Development

Transdermal delivery, although challenging, has significant advantages over delivery by oral or parenteral means. The avoidance of hepatic first-pass metabolism, improved patient compliance and ease of access to the absorbing membrane such as the skin, all add to the benefits of producing transdermal formulations. Transdermal drug delivery has now become one of the fastest growing sectors within the pharmaceutical industry.

 MedPharm has succeeded in bringing a number of transdermal products to market for its clients. It has experience in developing products using various transdermal platforms including:

  • Patches
  • MedSpray®
  • MedTherm®
  • Semi-solids
  • Active transdermal drug  delivery systems: Iontophoresis,   phonophoresis, microneedles, needleless injection, thermal ablation, skin perturbation

MedPharm offers clients services for transdermal product development that include:

  • Preformulation and formulation development
  • Specification development
  • Generic development
  • Lab scale and GMP/GLP manufacture
  • DSC/ATR-FTIR characterisation
  • Peel testing/tensiometer
  • Adhesivity characterisation/Skin retention
  • Drug release testing and human skin permeation testing
  • Accelerated stability testing
  • Trouble shooting: Adhesivity, physical and chemical stability issues, irritation and sensitisation problems